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KMID : 0811720140180030249
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Korean Journal of Physiology & Pharmacology
2014 Volume.18 No. 3 p.249 ~ p.254
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KHG26792 Inhibits Melanin Synthesis in Mel-Ab Cells and a Skin Equivalent Model
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Li Hai-Lan
Kim Jan-Di
Hahn Hoh-Gyu
Yun Jun
Jeong Hyo-Soon
Yun Hye-Young
Baek Kwang-Jin
Kwon Nyoun-Soo
Min Young-Sil
Park Kyoung-Chan
Kim Dong-Seok
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Abstract
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The purpose of this study is to characterize the effects of KHG26792 (3-(naphthalen-2-yl(propoxy) methyl)azetidine hydrochloride), a potential skin whitening agent, on melanin synthesis and identify the underlying mechanism of action. Our data showed that KHG26792 significantly reduced melanin synthesis in a dose-dependent manner. Additionally, KHG26792 downregulated microphthalmiaassociated transcription factor (MITF) and tyrosinase, the rate-limiting enzyme in melanogenesis, although tyrosinase was not inhibited directly. KHG26792 activated extracellular signal-regulated kinase (ERK), whereas an ERK pathway inhibitor, PD98059, rescued KHG26792-induced hypopigmentation. These results suggest that KHG26792 decreases melanin production via ERK activation. Moreover, the hypopigmentary effects of KHG26792 were confirmed in a pigmented skin equivalent model using Cervi cornus Colla (deer antler glue), in which the color of the pigmented artificial skin became lighter after treatment with KHG26792. In summary, our findings suggest that KHG26792 is a novel skin whitening agent.
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KEYWORD
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ERK, KHG26792, Melanogenesis, Skin equivalent, Tyrosinase
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